The supply chain in the urban centers is receiving increasing attention since, in recent years, it has been proven the importance of improving the efficiency of freight transport in the economic and social development of the regions. This is how new urban mobility initiatives have been gestating to deliver efficient merchandise, and thus reduce costs in last-mile deliveries and reduce negative externalities to the environment. In the case of Latin-American cities, freight transport faces problems of poor infrastructure, and little investment in new technologies that help improve deliveries. In this sense, cargo bicycles and tricycles have gained strength in urban centers, as profitable alternatives to make last-mile delivery more efficient. This mode represents low-investment on vehicles that are versatile to move through densely populated cities, and have a low environmental impact, and at the same time, this alternative brings economic benefits to both companies and freight carriers.