Biological control of phytopathogens has become an important alternative to the broad use of chemical pesticides. In our previous work, we have already characterized several strains of phylum Firmicutes (Bacillus, Paenibacillus, Brevibacillus), actinobacteria (Streptomyces), and even fungi against Pyricularia or Gauemannomyces in vitro as well as some of them at the greenhouse level as biocontroller and promoter microorganisms. Polyinoculum application can boost biological control, but we do not know the scope of the drench application of a poly-inoculum on plant. The aim of this research is to identify a poly-inoculum to drench application that can control rice phytopathogens and their effects on the plant. The results reached here will improve the sustainably of agroecosystems in the small, medium, and long term due to a decrease in chemical pesticides to conserve soil biodiversity, and soil health.