Proyectos
Monitoring the responsiveness of T and antigen presenting cell compartments in breast cancer patients is useful to predict clinical tumor response to neoadjuvant chemotherapy
Resumen
Background: Vaccination of mice with tumors treated with Doxorubicin promotes a T cell immunity that relies on dendritic cell (DC) activation and is responsible for tumor control in vaccinated animals. Despite Doxorubicin in combination with Cyclophosphamide (A/C) is widely used to treat breast cancer patients, the stimulating effect of A/C on T and APC compartments and its correlation with patient¿s clinical response remains to be proved. Methods: In this prospective study, we designed an in vitro system to monitor various immunological readouts in PBMCs obtained from a total of 17 breast cancer patients before, and after neoadjuvant anti-tumor therapy with A/C. Results: The results show that before treatment, T cells and DCs, exhibit a marked unresponsiveness to in vitro stimulus: whereas T cells exhibit poor TCR internalization and limited expression of CD154 in response to anti-CD3/CD28/CD2 stimulation, DCs secrete low levels of IL-12p70 and limited CD83 expression in response to
Convocatoria
Nombre de la convocatoria:CONVOCATORIA DE APOYO ECONÓMICO PARA LA PUBLICACIÓN EN REVISTAS INTERNACIONALES INDEXADAS EN MEDLINE DE ARTÍCULOS DE INVESTIGACIÓN -PLAN DE ACCIÓN 2106-
Modalidad:CONVOCATORIA DE APOYO ECONÓMICO PARA LA PUBLICACIÓN EN REVISTAS INTERNACIONALES INDEXADAS EN MEDLINE
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