Proyectos
IN VITRO ANTIPLASMODIAL ACTIVITY OF EXTRACT FROM Azadirachta indica CELL CULTURE
Resumen
Plasmodium falciparum is one parasite responsible of malaria, a disease causing of thousands of deaths every year. Treatment of malaria is very difficult because of parasites generate resistance to conventional drugs. Nowadays, researchers are focused on developing new treatments to control it. A possible alternative are the secondary metabolites produced by neem tree (Azadirachta indica) which have shown in vitro antiplasmodial activity. The in vitro antiplasmodial activity of extract and some fractions from A. indica cell culture was evaluated on chloroquine-resistant P. falciparum (FCR3) strains. The activity showed by the extract was promising (IC50 6.14 ¿g/ml). IC50 of hexane fraction was 13.66 ¿g/ml and dichloromethane fraction, 9.80 ¿g/ml. As far as our knowledge, this is the first report that shows the antiplasmodial effect of extract from A. indica cell culture. With these results, this extract could be profiled as future alternative to treat and control malaria.
Convocatoria
Nombre de la convocatoria:CONVOCATORIA PARA LA VISIBILIDAD INTERNACIONAL DE LA PRODUCCIÓN ACADÉMICA DE LA FACULTAD DE CIENCIAS MEDIANTE EL APOYO PARA TRADUCCIÓN Y/O CORRECCIÓN DE ESTILO DE ARTÍCULOS DE INVESTIGACIÓN
Modalidad:Modalidad 2. Revisión de estilo de artículos completos que vayan a ser sometidos o hayan sido aprobados para su publicación en revistas indexadas en ISI Web Of Knowledge o Scopus del Elsevier.
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