Castro-Vega LJ, Jouravleva K, Ortiz-Montero P, Liu WY, Galeano JL, Romero M, Popova T, Bacchetti S, Vernot JP, Londoño-Vallejo A.:
The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells. Carcinogenesis. 2015 Jul 13. pii: bgv101. [Epub ahead of print]
Rodríguez-Pardo VM, Aristizabal JA, Jaimes D, Quijano SM, de los Reyes I, Herrera MV, Solano J, Vernot JP.:
Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia. Hematol Oncol Stem Cell Ther. 2013 Sep-Dec;6(3-4):89-100. doi: 10.1016/j.hemonc.2013.09.002. Epub 2013 Oct 24
Rodríguez-Pardo VM, Vernot JP.:
Mesenchymal stem cells promote a primitive phenotype CD34+c-kit+ in human cord blood-derived hematopoietic stem cells during ex vivo expansión. Cell Mol Biol Lett. 2013 Mar;18(1):11-33. doi: 10.2478/s11658-012-0036-1. Epub 2012 Oct 27.
Perdomo-Arciniegas AM, Vernot JP.:
Optimised cord blood sample selection for small¿scale CD34+ cell immunomagnetic isolation. Mol Med Rep. 2012 Mar;5(3):749-52. doi: 10.3892/mmr.2011.733. Epub 2011 Dec 22.
Perdomo-Arciniegas AM, Vernot JP.:
Co-culture of hematopoietic stem cells with mesenchymal stem cells increases VCAM-1-dependent migration of primitive hematopoietic stem cells. Int J Hematol. 2011 Dec;94(6):525-32. doi: 10.1007/s12185-011-0970-0. Epub 2011 Nov 30.
Vernot JP, Londono-Vallejo A.
:
Telomere-driven chromosome instability and cell senescence: A dual mechanism in tumorigenesis. 2014. Aging:
is it a disease? V Forum. 27 September 2014, Frankfurt am Main. Fondaziones Ibsa for scientific research.
Paola Ortiz-Montero1, Arturo Londoño-Vallejo2,3 and Jean-Paul Vernot1:
Senescence-associated IL-6 and IL-8 cytokines induce a self- and crossreinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line.Cell Communication and Signaling (2017) 15:17
Natalia¿Del Pilar Vanegas and Jean¿Paul Vernot*:
Loss of quiescence and self¿renewal capacity of hematopoietic stem cell in an in vitro leukemic niche.
Exp Hematol Oncol (2017) 6:2
Ximena Bonilla ,1 Natalia-Del Pilar Vanegas ,1 and Jean Paul Vernot 1,2:
Acute Leukemia Induces Senescence and Impaired Osteogenic
Differentiation in Mesenchymal Stem Cells Endowing Leukemic
Cells with Functional Advantages.
Stem Cells International
Volume 2019, Article ID 3864948, 16 pages
Paola Fernanda Ruiz-Aparicio 1 , Natalia-Del Pilar Vanegas 1 , Gloria Inés Uribe 2,3, Paola Ortiz-Montero 1, Camila Cadavid-Cortés 1, Jimmy Lagos 2, Jessica Flechas-Afanador 2, Adriana Linares-Ballesteros 2 and Jean-Paul Vernot 1,4,*:
Dual Targeting of Stromal Cell Support and Leukemic Cell Growth by a Peptidic PKC Inhibitor Shows effectiveness against B-ALL.Int. J. Mol. Sci. 2020, 21, 3705; doi:10.3390/ijms21103705
Paola Fernanda Ruiz-Aparicio 1 , Gloria Inés Uribe 2,3, Adriana Linares-Ballesteros 3 and Jean-Paul Vernot 1,4,*:
Sensitization to Drug Treatment in Precursor B-Cell Acute
Lymphoblastic Leukemia Is Not Achieved by Stromal NF-B
Inhibition of Cell Adhesion but by Stromal PKC-Dependent
Inhibition of ABC Transporters Activity.Molecules 2021, 26, 5366. https://doi.org/10.3390/molecules26175366
P. M. Rojas-Zambrano 1, J. E. Meyer-Herrera 1, P. F. Ruiz-Aparicio 1,¿ and J. P. Vernot 1,2,*:
Simultaneously Targeting Two Coupled Signalling Molecules in the Mesenchymal Stem Cell Support Efficiently Sensitises the Multiple Myeloma Cell Line H929 to Bortezomib.
Int. J. Mol. Sci. 2023, 24, 8157. https://doi.org/10.3390/ijms24098157
Ángel Cortés Santiago1 | Rojas Zambrano Paula¿Manuela1 | Vernot Jean¿Paul1,2:
Favorable and poor prognosis B¿cell precursor acute lymphoblastic leukemia subtypes reveal distinct leukemic cell properties when interacting with mesenchymal stem cells, differentially modifying their cell stemness and leukemia chemoresistance.
J. Cell Commun. Signal. 2025;e70009.
